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Monday, August 3, 2020 | History

2 edition of Electron capture gas chromatography of drugs found in the catalog.

Electron capture gas chromatography of drugs

Per Hartvig

Electron capture gas chromatography of drugs

studies on amine derivatives

by Per Hartvig

  • 355 Want to read
  • 36 Currently reading

Published by Dept. of Analytical Chemistry, Faculty of Pharmacy, University of Uppsala in Uppsala .
Written in English

    Subjects:
  • Amines -- Analysis.,
  • Gas chromatography.

  • Edition Notes

    StatementPer Hartvig.
    Classifications
    LC ClassificationsRS431.A57 H37
    The Physical Object
    Pagination26 p. ;
    Number of Pages26
    ID Numbers
    Open LibraryOL4477846M
    LC Control Number79305628

    Gas chromatography–mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC-MS include drug detection, fire investigation, environmental analysis, explosives investigation, and identification of unknown samples, including that of material samples obtained. An electron capture detector (ECD) is a device for detecting atoms and molecules in a gas through the attachment of electrons via electron capture device was invented in by James Lovelock and is used in gas chromatography to detect trace amounts of .

    Application of two-dimensional gas chromatography with electron capture chemical ionization mass spectrometry to the detection of nor-Delta9-tetrahydrocannabinolcarboxylic acid (THC-COOH) in hair. Moore C(1), Rana S, Coulter C, Feyerherm F, Prest H. Title: Electron-Capture Mass Spectrometry: A Powerful Tool in Biomedical Trace Level Analysis VOLUME: 11 ISSUE: 12 Author(s):H. J. Leis, G. Fauler, G. N. Rechberger and W. Windischhofer Affiliation:Department of Analytical Biochemistry and Mass Spectrometry, Auenbruggerpl AGraz, Austria Keywords:resonance electron capture, mass spectrometry, negative ion, chemical .

    Abstract. 1 A gas chromatographic method using electron capture detection is described for the estimation of three acidic metabolites of dopamine, 4-hydroxymethoxyphenylacetic acid (homovanillic acid, HVA), 3,4-dihydroxyphenylacetic acid (DOPAC) and 3-hydroxymethoxyphenylacetic acid (homo-isovanillic acid, iso-HVA). Using these techniques permits improved detection and chromatography of some illicit drugs and their manufacturing by-products. This review focuses on the use of chemical derivatization in conjunction with gas chromatography-flame ionization detection, gas chromatography-electron capture detection, gas chromatography-mass spectrometry, high.


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Electron capture gas chromatography of drugs by Per Hartvig Download PDF EPUB FB2

Electron capture detector: In electron capture detector (ECD), the eluent coming from the gas chromatographic column passes through a slow electron beam. An analyte containing electronegative atoms, such as nitrogen, ‘captures’ electrons from the constant electron current, producing a signal by decreasing this current.

David S. Hage, in Principles and Applications of Clinical Mass Spectrometry, Electron Capture Detector. The ECD is another example of a selective GC detector. The operation of an ECD is based on the capture of secondary electrons by electronegative compounds that are eluting from the column.

12,21,22 High-energy electrons, or beta particles, are provided in an ECD by a radioactive source. Abstract. A sensitive electron-capture gas–liquid-chromatographic method for the determination of sub-nanogram quantities of prostaglandin F 2α was developed.

The method is based on the sub-microgram scale conversion of the prostaglandin into the electron-capturing pentafluorobenzyl ester, and analysis of the latter as the tris-trimethylsilyl ether. Gas chromatography—also referred to as gas-liquid chromatography (GLC)—is a specific type of chromatography that utilizes an inert gaseous mobile phase and a liquid stationary phase.

3 Instrumentation continues to improve, but the basics of a gas chromatograph—the instrument used to perform GC that bears the same abbreviation—have not. Search in this book series. Electron Capture Theory and Practice in Chromatography.

Edited by A. Zlatkis, C.F. Poole. Vol Pages iii-xii, () Chapter 8 Sensitive derivatives for the determination of organic compounds by electron-capture gas chromatography. Colin F. Poole, Albert Zlatkis. Pages Download PDF. The corona discharge used to generate positive and negative ions under conventional atmospheric pressure chemical ionization conditions also provides a source of gas-phase electrons.

This is thought to occur by displacement of electrons from the nitrogen sheath gas. Therefore, suitable analytes can undergo electron capture in the gas phase in a manner similar to that observed for gas. Determination of opiates in biological samples by glass capillary gas chromatography with electron-capture detection.

Journal of Chromatography A(1), DOI: /S(00) Jörgen Vessman. Chapter 13 Biomedical applications of the electron-capture detector.

, DOI: /S(08) Comparison of ion mobility constants of selected drugs after capillary gas chromatography and capillary supercritical fluid chromatography. Glenn E. Spangler and Phil A. Lawless. Comparison between plasma chromatography and electron capture detector.

Determination of plasma 3-methoxyhydroxyphenylglycol by pulsed electron capture gas. Additionally, gas chromatography can be used to determine vapor pressure, heat of solution, and activity coefficients. Industries often use it to monitor processes to test for contamination or ensure a process is going as planned.

Chromatography can test blood alcohol, drug purity, food purity, and essential oil quality. Purchase Gas Chromatography - 1st Edition.

Print Book & E-Book. ISBNIt is a simple procedure to tag many biomolecules and drugs with an electron-capturing group such as the pentafluorobenzyl moiety before analysis. Pentafluorobenzyl derivatives have previously been used as electron capturing derivatives because they undergo dissociative electron capture in the gas phase to generate negative ions through the.

The stationary phase is either a solid adsorbant, termed gas-solid chromatography (GSC), or a liquid on an inert support, termed gas-liquid chromatography (GLC). Introduction In early s, Gas chromatography (GC) was discovered by Mikhail Semenovich Tsvett as a separation technique to separate compounds.

Gas chromatographic–mass spectrometric analysis of hydroxylamine for monitoring the metabolic hydrolysis of metalloprotease inhibitors in rat and human liver microsomes.

Journal of Chromatography B: Biomedical Sciences and Applications(1). Wardencki, in Encyclopedia of Separation Science, Conclusions.

Gas chromatography, especially high resolution gas chromatography, perhaps more than other methods, fulfils the requirements needed for the analysis and structure elucidation of multicomponent environmental mixtures in which different sulfur species can be present in nanogram or picogram amounts.

Image 8: A gas chromatograph with electron capture detector. Picture Source: What detectors are used in a gas chromatograph. Mass spectrometer – The majority of gas chromatography instruments have a mass spectrometer. The gas chromatograph separates the compounds and the mass spectrometer identifies the compound according to fragmentation pattern.

Anggard E. and Hankey A. () Derivatives of sympathomimetic amines for gas chromatography with electron capture detection and mass spectrometry Acta Chem Stand.

23, – Google Scholar Bailey D. and Guba J J. () Gas-chromatographic analysis for chlorpromazine and some of its metabolites in human serum, with use of a nitrogen. Purchase Gas Chromatography - 2nd Edition. Print Book & E-Book.

ISBNElectron capture ionization is the ionization of a gas phase atom or molecule by attachment of an electron to create an ion of the form A. The reaction is + − → − where the M over the arrow denotes that to conserve energy and momentum a third body is required (the molecularity of the reaction is three).

Electron capture can be used in conjunction with chemical ionization. Used/Expertly Refurbished Gas Chromatography Equipment for Sale. When you require properly calibrated, serviced, and tested scientific equipment to give you the specific results you need, GenTech Scientific is a proven and trusted partner.

[Show full abstract] and gas chromatography coupled with a mass detector (HS-GC/MS). Chromatographic separation was performed with a ZB-BAC1 column and the total time of.

Abstract. We used l of plasma for the determination of di-azepam. After the internal standard, prazepam, is added, the serum is directly extracted with diethyl ether, the ex-tract is evaporated, the residue is dissolved in ethanol, and the drug is measured by gas-liquid chromatography, with use of an electron capture detector.

Gas chromatography with electron capture detection for determination of hydroxylamine in seawater Marta T. Von Breymann, Marie A. De Angelis, and Louis I. Gordon Anal. Chem.,54 (7), pp –Chromatography Online - books and papers by RWP Scott. Figure Wave form of Electron Capture Detector Pulses.

In the inactive period of the wave form, electrons having thermal energy only will attached themselves readily to any electron capturing molecules present in the cell with the consequent production of negatively charged ions.